The effects of functional foods, such as Agaricus, Pleurotus cornucopiae (Paulet) Rolland var. citrinopileatus (Sing.) Ohira. , Hericium erinaceum, Arabinoxylan, Shark cartilage and Shark extracted lipid on growth of implanted Mouse LM8 Dunn osteosarcoma

The 137th meeting of the Japanese Sciety of Veterinary Science

The effects of functional foods, such as Agaricus, Pleurotus cornucopiae (Paulet) Rolland var. citrinopileatus (Sing.) Ohira. , Hericium erinaceum, Arabinoxylan, Shark cartilage and Shark extracted lipid on growth of implanted Mouse LM8 Dunn osteosarcoma.

Nobuhide Kido1, Satoshi Takagi1, Kenjiro Shimada2, Tsuyoshi Kadozawa1, Masahiro Okumura1, Toru Fujinaga1
  1. Department of Veterinary medicine, Hokkaido University
  2. Kyowa Hakko co., ltd

Abstract

For the test groups, feed with supplement was started three weeks before LM8 highly lung metastasizing cell line from mouse osteosarcoma was implanted into dorsal subcutaneous tissue and the mice were kept for six to seven weeks following the tumor injection. On the other hand, the control group was given feed without the supplement. In experiment 1, Agaricus, Pleurotus cornucopiae (Paulet) Rolland var. citrinopileatus (Sing.) Ohira. , Hericium erinaceum and Arabinoxylan did not show obvious effects on the growth of the implanted tumor. In experiment 2, Shark cartilage and Shark extracted lipid showed inhibition of growth in both the implanted and metastasized tumor. The effect of Shark extracted lipid was slightly stronger than that of Shark cartilage. In experiment 3, Shark extracted lipid decreased the number of blood vessels significantly. In this experiment, Shark extracted lipid showed a higher inhibition of tumor growth than experiment 2. Thus, Shark extracted lipid as a functional food which has anti-tumor activity is worth further investigation.

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