FASEB J. 2004 Jun;18(9):983-985

Angiogenesis in an in vivo model of adipose tissue development

Neels JG1, Thinnes T, Loskutoff DJ.
  1. The Scripps Research Institute, Department of Cell Biology, Division of Vascular Biology, La Jolla, California 92037, USA.


Little is known about angiogenesis in adipose tissue, primarily because of the absence of reliable model systems. The general aim of these studies was to determine whether fat pads that develop when cultured 3T3-F442A cells are injected under the skin of nude mice form a suitable in vivo model system to study neovascularization of developing adipose tissue. One specific aim was to provide initial information about the morphology, kinetics of neovascularization, and gene expression profiles of the developing fat pads; another was to determine whether their new vasculature originated from bone marrow-derived endothelial progenitor cells or from preexisting host vessels.

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