{"id":2426,"date":"2019-06-20T12:13:38","date_gmt":"2019-06-20T00:13:38","guid":{"rendered":"https:\/\/www.aoteapacific.co.nz\/jp\/?p=2426"},"modified":"2019-10-15T14:32:35","modified_gmt":"2019-10-15T01:32:35","slug":"angiogenesis-and-related-diseases","status":"publish","type":"post","link":"https:\/\/www.aoteapacific.co.nz\/jp\/angiogenesis\/angiogenesis-and-related-diseases.html","title":{"rendered":"\u8840\u7ba1\u65b0\u751f\u3068\u305d\u306e\u95a2\u9023\u3059\u308b\u75be\u60a3"},"content":{"rendered":"<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u306f\uff1f<\/h2>\r\n  <p>\u8840\u7ba1\u65b0\u751f\u306f\u751f\u7406\u3068\u75c5\u7406\u7684\u306a\u7279\u5b9a\u306e\u75be\u60a3\u306b\u307f\u3089\u308c\u3001\u7a2e\u3005\u306e\u5206\u5b50\u3084\u7d30\u80de\u306e\u95a2\u4e0e\u306b\u3088\u3063\u3066\u3001\u65b0\u3057\u3044\u8840\u7ba1\u304c\u5f62\u6210\u3055\u308c\u308b\u8907\u96d1\u306a\u904e\u7a0b\u3067\u3059\u3002\u8840\u7ba1\u65b0\u751f\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u75c5\u6c17\u3067\u751f\u3058\u3001\u3057\u304b\u3082\u3001\u305d\u308c\u305e\u308c\u306e\u75c5\u614b\u306e\u9032\u5c55\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u8840\u7ba1\u65b0\u751f\u304c\u95a2\u308f\u308b\u75be\u60a3\u306b\u306f\u3001\u60aa\u6027\u816b\u760d\uff08\u30ac\u30f3\uff09\u3068\u305d\u306e\u8ee2\u79fb\u3001\u76ae\u819a\u5149\u8001\u5316\u3001\u80a5\u6e80\uff08\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u3001\u30ea\u30a6\u30de\u30c1\u6027\u95a2\u7bc0\u708e\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <div class=\"img_center_h\">\r\n    <div class=\"label\">\u8840\u7ba1\u65b0\u751f\u3068\u305d\u306e\u95a2\u9023\u75be\u60a3<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.aoteapacific.co.nz\/jp\/wp-content\/uploads\/angiogenesis_and_related_diseases.jpg\" alt=\"\u8840\u7ba1\u65b0\u751f\u3068\u305d\u306e\u95a2\u9023\u3059\u308b\u75be\u60a3\"  \/>\r\n  <\/div><!--img_center_h-->\r\n<\/section>\r\n<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u304c\u3093\u53ca\u3073\u304c\u3093\u79fb\u8ee2<\/h2>\r\n  <p>\u60aa\u6027\u816b\u760d\uff08\u30ac\u30f3\uff09\u306f\u3001\u8840\u7ba1\u65b0\u751f\u306b\u3088\u308a\u6804\u990a\u3084\u9178\u7d20\u3092\u3088\u308a\u52b9\u7387\u826f\u304f\u53d6\u308a\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u305d\u308c\u3068\u540c\u6642\u306b\u8001\u5ec3\u7269\u3092\u9664\u53bb\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30ac\u30f3\u7d30\u80de\u306f\u6210\u9577\u3057\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u8ee2\u79fb\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u30ac\u30f3\u306b\u304a\u3051\u308b\u8840\u7ba1\u65b0\u751f\u6291\u5236\u306e\u52b9\u679c\u306f\u3001\u30ac\u30f3\u7d30\u80de\u3078\u306e\u8840\u6db2\u3092\u4ecb\u3057\u305f\u6804\u990a\u3084\u9178\u7d20\u306e\u4f9b\u7d66\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30ac\u30f3\u7d30\u80de\u3092\u9913\u6b7b\u3055\u305b\u308b\u3068\u3044\u3046\u8003\u3048\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <div class=\"img_center_h\">\r\n    <div class=\"label\">\u304c\u3093\u306e\u5897\u6b96\u3068\u8ee2\u79fb\u306bVEGF \u3068\u305d\u306e\u53d7\u5bb9\u4f53\u306e\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u4f5c\u7528<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.aoteapacific.co.nz\/jp\/wp-content\/uploads\/angiogenesis_cancer_tumor_vegf.jpg\" alt=\"\u304c\u3093\u306e\u5897\u6b96\u3068\u8ee2\u79fb\u306bVEGF \u3068\u305d\u306e\u53d7\u5bb9\u4f53\u306e\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u4f5c\u7528\" \/>\r\n  <\/div><!--img_center_h-->\r\n<\/section>\r\n<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u76ae\u819a\u8001\u5316<\/h2>\r\n  <p>\u76ae\u819a\u306e\u5149\u8001\u5316\u3068\u306f\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u3001\u76ae\u819a\u7d30\u80de\u304c\u708e\u75c7\u3092\u8d77\u3053\u3057\u3066\u3001\u6d3b\u6027\u9178\u7d20\u306a\u3069\u3092\u7523\u751f\u3057\u3001\u7d30\u80de\u5916\u57fa\u8cea\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\uff09\u3092\u5206\u89e3\u3055\u308c\u3001\u76ae\u819a\u306e\u30b7\u30ef\u5f62\u6210\u3001\u9ed2\u8272\u7d20\u306e\u6c88\u7740\u306a\u3069\u304c\u767a\u751f\u3057\u307e\u3059\u3002\u305d\u306e\u708e\u75c7\u3068\u4f34\u306b\u3001\u76ae\u819a\u306e\u8840\u7ba1\u3082\u8457\u3057\u304f\u5909\u5316\u3057\u3001\u7d2b\u5916\u7dda\u306e\u523a\u6fc0\u306b\u3088\u308a\u76ae\u819a\u306e\u8840\u7ba1\u65b0\u751f\u306e\u5f62\u6210\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\r\n  <div class=\"img_center_h\">\r\n    <div class=\"label\">\u7d2b\u5916\u7dda\u7167\u5c04\u306b\u3088\u308b\u30de\u30a6\u30b9\u76ae\u819a\u30b7\u30ef\u306e\u767a\u751f\u3068\u8840\u7ba1\u65b0\u751f\u306e\u5f62\u6210<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.aoteapacific.co.nz\/jp\/wp-content\/uploads\/angiogenesis_uv_skin.jpg\" alt=\"\u7d2b\u5916\u7dda\u7167\u5c04\u306b\u3088\u308b\u30de\u30a6\u30b9\u76ae\u819a\u30b7\u30ef\u306e\u767a\u751f\u3068\u8840\u7ba1\u65b0\u751f\u306e\u5f62\u6210\" \/>\r\n    <div class=\"reference\"><a href=\"https:\/\/www.aoteapacific.co.nz\/jp\/research\/publications\/j-invest-dermatol-2002.html\">\u53c2\u7167\uff1aJ Invest Dermatol 118:800- 805, 2002.<\/a><\/div>\r\n  <\/div><!--img_center_h-->\r\n  <p>\u76ae\u819a\u306e\u5149\u8001\u5316\u306f\u76ae\u819a\u306e\u8840\u7ba1\u65b0\u751f\u3068\u6df1\u304f\u95a2\u4fc2\u304c\u3042\u308a\u3001\u8840\u7ba1\u65b0\u751f\u306e\u6291\u5236\u3059\u308b\u306b\u3088\u3063\u3066\u3001\u76ae\u819a\u5149\u8001\u5316\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u4e7e\u766c<\/h2>\r\n  <p>\u4e7e\u766c\u306f\u3001\u8840\u7ba1\u65b0\u751f\u3092\u4f34\u3046\u708e\u75c7\u3067\u76ae\u819a\u3084\u95a2\u7bc0\u3092\u4fb5\u3059\u6162\u6027\u518d\u767a\u6027\u306e\u75be\u60a3\u3067\u3059\u3002\u901a\u5e38\u3001\u9c57\u5c51\u3092\u4f34\u3046\u7d05\u6591\u304c\u76ae\u819a\u306b\u73fe\u308c\u307e\u3059\u3002\u767a\u75b9\u306e\u5927\u304d\u3055\u3084\u5f62\u306f\u69d8\u3005\u3067\u3001\u6642\u306b\u306f\u767a\u75b9\u304c\u5168\u8eab\u306b\u53ca\u3076\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u904e\u5270\u306a\u5897\u52a0\u3001\u708e\u75c7\u7d30\u80de\u306e\u84c4\u7a4d\u3001\u904e\u5270\u306a\u8840\u7ba1\u65b0\u751f\u3092\u7279\u5fb4\u3068\u3057\u307e\u3059\u3002\u307e\u305f\u4e7e\u766c\u3067\u306f\u3001\u514d\u75ab\u5a92\u4ecb\u306b\u3088\u308bproangiogenic factors \u304c\u7523\u751f\u3055\u308c\u307e\u3059\u3002\u8840\u7ba1\u65b0\u751f\u3001\u8868\u76ae\u306e\u7d30\u80de\u5897\u6b96\u3001\u5c40\u6240\u306e\u6162\u6027\u7684\u306a\u708e\u75c7\u306e\u7d50\u679c\u3001\u767a\u75b9\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\r\n  <div class=\"img_center_h\">\r\n    <div class=\"label\">\u4e7e\u766c\u306e\u75c7\u72b6<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.aoteapacific.co.nz\/jp\/wp-content\/uploads\/angiogenesis_psoriasis.jpg\" alt=\"\u4e7e\u766c\u306e\u75c7\u72b6\" \/>\r\n    <div class=\"reference\">\u63d0\u4f9b\u5143\uff1aS. Grolom, Grikin Skin Inst, Michigan, USA<\/div>\r\n  <\/div><!--img_center_h-->\r\n<\/section>\r\n<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u30ea\u30a6\u30de\u30c1\u95a2\u7bc0\u708e<\/h2>\r\n  <div class=\"img_center_h\">\r\n    <div class=\"label\">\u30ea\u30a6\u30de\u30c1\u95a2\u7bc0\u708e<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.aoteapacific.co.nz\/jp\/wp-content\/uploads\/angiogenesis_rheumatoid_arthritis.jpg\" alt=\"\u30ea\u30a6\u30de\u30c1\u95a2\u7bc0\u708e\" \/>\r\n  <\/div><!--img_center_h-->\r\n  <p>\u30ea\u30a6\u30de\u30c1\u95a2\u7bc0\u708e\uff08Rheumatoid Arthritis; RA\uff09\u306f\u3001\u81ea\u5df1\u514d\u75ab\u304c\u4e3b\u306b\u624b\u8db3\u306e\u95a2\u7bc0\u3092\u4fb5\u3057\u3001\u3053\u308c\u306b\u3088\u308a\u95a2\u7bc0\u75db\u3001\u95a2\u7bc0\u306e\u5909\u5f62\u304c\u751f\u3058\u308b\u708e\u75c7\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3059\u3002\u30ea\u30a6\u30de\u30c1\u69d8\u95a2\u7bc0\u708e\u306f\u4e3b\u306b\u708e\u75c7\u6027\u306e\u75c7\u72b6\u3067\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u95a2\u7bc0\u6db2\u8154\u306e\u95a2\u7bc0\u8154\u3092\u8986\u3046\u5fae\u5c0f\u8840\u7ba1\u304b\u3089\u51fa\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u3001\uff34\u30ea\u30f3\u30d1\u7403\u306a\u3069\u306e\u708e\u75c7\u7d30\u80de\u306e\u8840\u7ba1\u5916\u904a\u8d70\u306b\u3088\u308a\u95a2\u7bc0\u8154\u81ea\u8eab\u306e\u5185\u5074\u306b\u59cb\u3058\u3081\u3001\u3053\u308c\u3089\u306e\u708e\u75c7\u7d30\u80de\u304c\u95a2\u7bc0\u8154\u3078\u306e\u9032\u5165\u306b\u3088\u308a\u708e\u75c7\u56e0\u5b50\u3068\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u56e0\u5b50\u3092\u751f\u7523\u3055\u305b\u3001\u708e\u75c7\u53cd\u5fdc\u3084\u7d71\u5236\u306e\u3068\u308c\u306a\u304f\u306a\u3063\u305f\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u80a5\u6e80<\/h2>\r\n  <p>\u80a5\u6e80\u307e\u305f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\uff08\u82f1 metabolic syndrome\u3001\u4ee3\u8b1d\u75c7\u5019\u7fa4\u3001\u5358\u306b\u30e1\u30bf\u30dc\u3068\u3082\uff09\u3068\u306f\u3001\u5185\u81d3\u8102\u80aa\u578b\u80a5\u6e80\uff08\u5185\u81d3\u80a5\u6e80\u30fb\u8179\u90e8\u80a5\u6e80\uff09\u306b\u9ad8\u8840\u7cd6\u30fb\u9ad8\u8840\u5727\u30fb\u9ad8\u8102\u8840\u75c7\u306e\u3046\u30612\u3064\u4ee5\u4e0a\u3092\u5408\u4f75\u3057\u305f\u72b6\u614b\u3092\u3044\u3044\u307e\u3059\u3002<\/p>\r\n  <p>1998\u5e74\u3001\u30a2\u30e1\u30ea\u30ab Yale \u5927\u5b66\u3067\u306f\u30ec\u30d7\u30c1\u30f3\uff08Leptin\u3001\u98df\u7269\u6442\u53d6\u91cf\u3092\u898f\u5236\u3059\u308b\u30db\u30eb\u30e2\u30f3\uff09\u306f\u8840\u7ba1\u65b0\u751f\u8a98\u5c0e\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u5224\u660e\u3057\u3001\u521d\u3081\u3066Science\u8a8c\u3067\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u80a5\u6e80\u306e\u5f62\u6210\u306f\u8102\u8cea\u751f\u6210\uff08Adipogenesis)\u3068\u8840\u7ba1\u65b0\u751f(Angiogenesis)\u304a\u3088\u3073\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u518d\u5efa\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\r\n  <div class=\"img_center_h\">\r\n    <div class=\"label\">\u8102\u80aa\u7d44\u7e54\u306b\u5bfe\u3059\u308b\u8840\u7ba1\u65b0\u751f\u3068\u30ec\u30d7\u30c1\u30f3\u306e\u95a2\u4fc2<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.aoteapacific.co.nz\/jp\/wp-content\/uploads\/angiogenesis_obesity.jpg\" alt=\"\u8102\u80aa\u7d44\u7e54\u306b\u5bfe\u3059\u308b\u8840\u7ba1\u65b0\u751f\u3068\u30ec\u30d7\u30c1\u30f3\u306e\u95a2\u4fc2\" \/>\r\n    <div class=\"reference\"><a href=\"https:\/\/www.aoteapacific.co.nz\/jp\/research\/publications\/faseb-j-2004.html\">\u53c2\u7167\uff1aFASEB J. 2004 Jun;18(9):983-985<\/a><\/div>\r\n  <\/div><!--img_center_h-->\r\n  <p>\u8fd1\u5e74\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3092\u6cbb\u7642\u53ca\u3073\u4e88\u9632\u306e\u305f\u3081\u306b\u3001\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u307e\u305f\u4ee3\u8b1d\u8abf\u7bc0\u56e0\u5b50\u306e\u8840\u7ba1\u65b0\u751f\u5236\u5fa1\u4f5c\u7528\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8102\u80aa\u7d44\u7e54\u5185\u306e\u8840\u7ba1\u65b0\u751f\u306e\u8abf\u7bc0\u3092\u4ecb\u3057\u3066\u8102\u80aa\u7d44\u7e54\u306e\u5897\u6b96\u30fb\u751f\u5b58\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u80a5\u6e80\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3082\u63d0\u5531\u3055\u308c\u3066\u304a\u308a\u3001\u80a5\u6e80\u75c5\u614b\u306b\u304a\u3051\u308b\u8840\u7ba1\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section>\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u3068\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7<\/h2>\r\n  <p>\u7db2\u819c\u306b\u306f\u773c\u7403\u306b\u6804\u990a\u3084\u9178\u7d20\u3092\u4f9b\u7d66\u3059\u308b\u305f\u3081\u306e\u7d30\u3044\u8840\u7ba1\u304c\u5f35\u308a\u3081\u3050\u3089\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9ad8\u8840\u7cd6\u72b6\u614b\u304c\u9577\u304f\u7d9a\u304f\u3068\u8840\u7ba1\u304c\u8a70\u307e\u3063\u305f\u308a\u3001\u5207\u308c\u305f\u308a\u3059\u308b\u8840\u7ba1\u969c\u5bb3\u304c\u751f\u3058\u307e\u3059\u3002\u3053\u306e\u8840\u7ba1\u969c\u5bb3\u3092\u88dc\u3046\u305f\u3081\u767a\u9054\u3057\u305f\u8840\u7ba1\u65b0\u751f\u306f\u8106\u5f31\u3067\u3042\u308a\u7834\u308c\u3084\u3059\u304f\u3001\u727d\u5f15\u6027\u7db2\u819c\u5265\u96e2\u3001\u785d\u5b50\u4f53\u51fa\u8840\u306a\u3069\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\r\n  <p>\u751f\u4f53\u9632\u5fa1\u306e\u4e00\u90e8\u3068\u3057\u3066\u306e\u8840\u7ba1\u65b0\u751f\u3068\u3044\u3046\u73fe\u8c61\u306b\u3088\u308a\u3001\u9006\u306b\u785d\u5b50\u4f53\u51fa\u8840\u306a\u3069\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3057\u3001\u305d\u308c\u306b\u4f34\u3044\u8996\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u5931\u660e\u306b\u81f3\u308b\u5371\u967a\u304c\u751f\u3058\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u3067\u306f\u3001\u65b0\u751f\u8840\u7ba1\u306e\u767a\u751f\u9632\u6b62\u3084\u6d88\u5931\u3092\u76ee\u7684\u306b\u3001\u7db2\u819c\u306b\u30ec\u30fc\u30b6\u30fc\u5149\u7dda\u3092\u7167\u5c04\u3059\u308b\u5149\u51dd\u56fa\u7642\u6cd5\u304c\u884c\u306a\u308f\u308c\u3066\u304a\u308a\u52b9\u679c\u3092\u3042\u3052\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u8840\u7ba1\u65b0\u751f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u75c5\u614b\u306e\u9032\u884c\u3092\u9632\u6b62\u3057\u5931\u660e\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section>\r\n  <b>\u53c2\u8003\u6587\u732e<\/b>\r\n  <ol class=\"references\">\r\n    <li><a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2005.06.081\" target=\"_blank\" rel=\"noopener noreferrer\">Hicklin DJ, Ellis LM. Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis. J Clin Oncol. 2005 Feb 10;23(5):1011-27<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.aoteapacific.co.nz\/jp\/research\/publications\/j-invest-dermatol-2002.html\">Kiichiro Yano, Hajimu Oura, and Michael Detmar. Targeted Overexpression of the Angiogenesis InhibitorThrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage. J Invest Dermatol 118:800- 805, 2002.<\/a><\/li>\r\n    <li><a href=\"https:\/\/science.sciencemag.org\/content\/281\/5383\/1582\" target=\"_blank\" rel=\"noopener noreferrer\">Barinaga M. Leptin Sparks Blood Vessel Growth. Science, 281(5383):1582, 1998<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.aoteapacific.co.nz\/jp\/research\/publications\/faseb-j-2004.html\">Neels JG, Thinnes T, Loskutoff DJ. Angiogenesis in an in vivo model of adipose tissue development. FASEB J. 2004 Jun;18(9):983-985<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.aoteapacific.co.nz\/jp\/research\/publications\/diabetes-2004.html\">Suganami E, Takagi H, Ohashi H, Suzuma K, Suzuma I, Oh H, Watanabe D, Ojima T, Suganami T, Fujio Y, Nakao K, Ogawa Y, Yoshimura N. Leptin Stimulates Ischemia-Induced Retinal Neovascularization. Diabetes. 2004 Sep;53(9):2443-2448<\/a><\/li>\r\n  <\/ol>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"\u8840\u7ba1\u65b0\u751f\u306f\u3055\u307e\u3056\u307e\u306a\u75c5\u6c17\u3067\u751f\u3058\u3001\u305d\u308c\u305e\u308c\u306e\u75c5\u614b\u306e\u9032\u5c55\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002","protected":false},"author":89,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[115],"tags":[],"class_list":["post-2426","post","type-post","status-publish","format-standard","hentry","category-angiogenesis"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/posts\/2426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/users\/89"}],"replies":[{"embeddable":true,"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/comments?post=2426"}],"version-history":[{"count":29,"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/posts\/2426\/revisions"}],"predecessor-version":[{"id":2558,"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/posts\/2426\/revisions\/2558"}],"wp:attachment":[{"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/media?parent=2426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/categories?post=2426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.aoteapacific.co.nz\/jp\/wp-json\/wp\/v2\/tags?post=2426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}