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痴呆症·阿尔兹海默症与维生素B6,B12,叶酸的关联性癡呆癥·阿爾茲海默癥與維生素B6,B12,葉酸的關聯性

癡呆癥·的危險因子因研究已經變得明確。

“Vitamin therapy with folic acid, alone or in combination with vitamins B6 and B12, and dietary supplementation with enriched cereal-grain products and breakfast cereals containing folate can reduce plasma homocysteine levels.”

研究概括的詳情請在這裏查看。

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer’s Disease

Sudha Seshadri, M.D., Alexa Beiser, Ph.D., Jacob Selhub, Ph.D., Paul F. Jacques, Sc.D., Irwin H. Rosenberg, M.D., Ralph B. D’Agostino, Ph.D., Peter W.F. Wilson, M.D., and Philip A. Wolf, M.D.
N Engl J Med 2002; 346:476-483

METHODS

A total of 1092 subjects without dementia (667 women and 425 men; mean age, 76 years) from the Framingham Study constituted our study sample. We examined the relation of the plasma total homocysteine level measured at base line and that measured eight years earlier to the risk of newly diagnosed dementia on follow-up. We used multivariable proportional-hazards regression to adjust for age, sex, apolipoprotein E genotype, vascular risk factors other than homocysteine, and plasma levels of folate and vitamins B12 and B6.

RESULTS

Over a median follow-up period of eight years, dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer’s disease. The multivariable-adjusted relative risk of dementia was 1.4 (95 percent confidence interval, 1.1 to 1.9) for each increase of 1 SD in the log-transformed homocysteine value either at base line or eight years earlier. The relative risk of Alzheimer’s disease was 1.8 (95 percent confidence interval, 1.3 to 2.5) per increase of 1 SD at base line and 1.6 (95 percent confidence interval, 1.2 to 2.1) per increase of 1 SD eight years before base line. With a plasma homocysteine level greater than 14 μmol per liter, the risk of Alzheimer’s disease nearly doubled.

graph

CONCLUSIONS

An increased plasma homocysteine level is a strong, independent risk factor for the development of dementia and Alzheimer’s disease.

関連商品

维他命B6,B12,叶酸综合锭

维他命B6,B12,叶酸综合锭

隨著年齡增長,人體缺乏B6,B12,葉酸三種營養素的比例增高且由食物獲得的攝取量往往不足,本款綜合錠能對神經系統產生保護效果、有效降低心血管疾病的風險。

痴呆症·的危险因子因研究已经变得明确。

“Vitamin therapy with folic acid, alone or in combination with vitamins B6 and B12, and dietary supplementation with enriched cereal-grain products and breakfast cereals containing folate can reduce plasma homocysteine levels.”

研究概括的详情请在这里查看

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer’s Disease

Sudha Seshadri, M.D., Alexa Beiser, Ph.D., Jacob Selhub, Ph.D., Paul F. Jacques, Sc.D., Irwin H. Rosenberg, M.D., Ralph B. D’Agostino, Ph.D., Peter W.F. Wilson, M.D., and Philip A. Wolf, M.D.
N Engl J Med 2002; 346:476-483

METHODS

A total of 1092 subjects without dementia (667 women and 425 men; mean age, 76 years) from the Framingham Study constituted our study sample. We examined the relation of the plasma total homocysteine level measured at base line and that measured eight years earlier to the risk of newly diagnosed dementia on follow-up. We used multivariable proportional-hazards regression to adjust for age, sex, apolipoprotein E genotype, vascular risk factors other than homocysteine, and plasma levels of folate and vitamins B12 and B6.

RESULTS

Over a median follow-up period of eight years, dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer’s disease. The multivariable-adjusted relative risk of dementia was 1.4 (95 percent confidence interval, 1.1 to 1.9) for each increase of 1 SD in the log-transformed homocysteine value either at base line or eight years earlier. The relative risk of Alzheimer’s disease was 1.8 (95 percent confidence interval, 1.3 to 2.5) per increase of 1 SD at base line and 1.6 (95 percent confidence interval, 1.2 to 2.1) per increase of 1 SD eight years before base line. With a plasma homocysteine level greater than 14 μmol per liter, the risk of Alzheimer’s disease nearly doubled.

graph

CONCLUSIONS

An increased plasma homocysteine level is a strong, independent risk factor for the development of dementia and Alzheimer’s disease.

関連商品

维他命B6,B12,叶酸综合锭

维他命B6,B12,叶酸综合锭

随着年龄增长,人体缺乏B6,B12,叶酸三种营养素的比例增高且由食物获得的摄取量往往不足,本款综合锭能对神经系统产生保护效果、有效降低心血管疾病的风险。

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